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KMID : 1150720160050010003
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Integrative Medicine Research
2016 Volume.5 No. 1 p.3 ~ p.10
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Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytes
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Youm Jae-Boum
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Abstract
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Embryonic stem cell-derived cardiomyocytes (ESC-CMs) hold great interest in many fields of research including clinical applications such as stem cell and gene therapy for cardiac repair or regeneration. ESC-CMs are also used as a platform tool for pharmacological tests or for investigations of cardiac remodeling. ESC-CMs have many different aspects of morphology, electrophysiology, calcium handling, and bioenergetics compared with adult cardiomyocytes. They are immature in morphology, similar to sinus nodal-like in the electrophysiology, higher contribution of trans-sarcolemmal Ca2+ influx to Ca2+ handling, and higher dependence on anaerobic glycolysis. Here, I review a detailed electrophysiology and Ca2+ handling features of ESC-CMs during differentiation into adult cardiomyocytes to gain insights into how all the developmental changes are related to each other to display cardinal features of developing cardiomyocytes.
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KEYWORD
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calcium handling, cardiomyocytes, electrophysiology, embryonic stem cell, ion channels
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